Research Paper Volume 13, Issue 21 pp 24339—24348

Deletion of miR-15a inhibited glioma development via targeting Smad7 and inhibiting EMT pathway

High expression of miR-15a indicated a poor prognosis of glioma. (A) Microarray analysis used to identify the differential expressed miRNAs in 3 paired glioma tissues. (B) The mRNA expression of miR-15a in adjacent normal tissues and cancer tissues of glioma was detected by qRT-PCR. (C) MiR-15a level in normal astrocytes and glioma cell lines (U87 and SHG139) was measured. (D) The overall survival rate of glioma patients with high or low expression of miR-15a. Data were expressed as mean ± SD.*P

Figure 1. High expression of miR-15a indicated a poor prognosis of glioma. (A) Microarray analysis used to identify the differential expressed miRNAs in 3 paired glioma tissues. (B) The mRNA expression of miR-15a in adjacent normal tissues and cancer tissues of glioma was detected by qRT-PCR. (C) MiR-15a level in normal astrocytes and glioma cell lines (U87 and SHG139) was measured. (D) The overall survival rate of glioma patients with high or low expression of miR-15a. Data were expressed as mean ± SD.*P < 0.05.