Research Paper Volume 13, Issue 21 pp 24449—24463

Small interfering RNA-induced silencing lncRNA PVT1 inhibits atherosclerosis via inactivating the MAPK/NF-κB pathway

PVT1 is highly expressed in AS patients. (A) Relative PVT1 expression in serum of AS patients and healthy controls detected by qRT-PCR; (B) Levels of IL-6, IL-1β and TNF-α in serum of AS patients detected by ELISA. * p  0.05, ** p  0.01. PVT1, plasmacytoma variant translocation 1; AS, atherosclerosis; CRP, C-reactive protein; IL, interleukin; TNF-α, tumor necrosis factor-alpha.

Figure 1. PVT1 is highly expressed in AS patients. (A) Relative PVT1 expression in serum of AS patients and healthy controls detected by qRT-PCR; (B) Levels of IL-6, IL-1β and TNF-α in serum of AS patients detected by ELISA. * p < 0.05, ** p < 0.01. PVT1, plasmacytoma variant translocation 1; AS, atherosclerosis; CRP, C-reactive protein; IL, interleukin; TNF-α, tumor necrosis factor-alpha.