Research Paper Volume 13, Issue 21 pp 24449—24463

Small interfering RNA-induced silencing lncRNA PVT1 inhibits atherosclerosis via inactivating the MAPK/NF-κB pathway

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Figure 5.

Silencing PVT1 promotes apoptosis and cell cycle arrest of HA-VSMC. (A) Relative apoptosis rate of HA-VSMCs detected by flow cytometry; (B) Relative cell cycle distribution of HA-VSMCs; (C) Relative levels of apoptosis-related proteins detected by Western blot; compared to the oe-NC group, *p < 0.05, ** p < 0.01; compared to the si-NC group, # p < 0.05, ## p < 0.01. PVT1, plasmacytoma variant translocation 1; HA-VSMCs, human arterial vascular smooth muscle cells; oe, overexpression; NC, negative control.