Research Paper Volume 13, Issue 22 pp 24621—24639

Construction of a genome instability-derived lncRNA-based risk scoring system for the prognosis of hepatocellular carcinoma

Identification and functional annotations of genomic instability-related lncRNAs. (A) GU-like group and GS-like group identification according to the top 25% samples and the last 25% ones in the ranking list of cumulative somatic mutations. The left blue cluster is GS-like group, and the right red cluster is GU-like group. (B) Unsupervised clustering of 364 HCC patients based on the expression pattern of 88 candidate genomic instability-related lncRNAs. The left orange cluster is GU-like group, and the right blue cluster is GS-like group. (C) Boxplots of somatic mutations in the GU-like group and GS-like group. Somatic cumulative mutations in the GU-like group are significantly higher than those in the GS-like group. (D) Coexpression network of genomic instability-related lncRNAs and mRNAs. The red circles represent mRNAs, and the blue circles represent lncRNAs. (E, F) Functional enrichment analysis of GO and KEGG for mRNAs co-expressed lncRNAs.

Figure 1. Identification and functional annotations of genomic instability-related lncRNAs. (A) GU-like group and GS-like group identification according to the top 25% samples and the last 25% ones in the ranking list of cumulative somatic mutations. The left blue cluster is GS-like group, and the right red cluster is GU-like group. (B) Unsupervised clustering of 364 HCC patients based on the expression pattern of 88 candidate genomic instability-related lncRNAs. The left orange cluster is GU-like group, and the right blue cluster is GS-like group. (C) Boxplots of somatic mutations in the GU-like group and GS-like group. Somatic cumulative mutations in the GU-like group are significantly higher than those in the GS-like group. (D) Coexpression network of genomic instability-related lncRNAs and mRNAs. The red circles represent mRNAs, and the blue circles represent lncRNAs. (E, F) Functional enrichment analysis of GO and KEGG for mRNAs co-expressed lncRNAs.