Research Paper Volume 13, Issue 22 pp 24640—24654

PPARα agonist relieves spinal cord injury in rats by activating Nrf2/HO-1 via the Raf-1/MEK/ERK pathway

PPARα agonist improved BBB score and relieved SCI in SCI rats. (A–D) The rats were randomly divided into sham-operation group (Sham group), rat SCI model group (SCI group), SCI + peroxisome proliferator-activated receptor alpha (PPARα) agonist PEA group (PEA group). The SCI rat model was established using modified Allen's method. The rats in the PEA group were intraperitoneally injected with PEA (2 mg/kg). The recovery of motor function in SCI rats evaluated by Basso, Beattie and Bresnahan locomotor rating scale (BBB scale); Hematoxylin-eosin staining (scale bar = 50 μm); Nissl staining;. The body weight of the rats was recorded and the animal behavior, including 50% withdrawal threshold and withdrawal latency, was analyzed in the rats. ‘*’ indicates p

Figure 1. PPARα agonist improved BBB score and relieved SCI in SCI rats. (AD) The rats were randomly divided into sham-operation group (Sham group), rat SCI model group (SCI group), SCI + peroxisome proliferator-activated receptor alpha (PPARα) agonist PEA group (PEA group). The SCI rat model was established using modified Allen's method. The rats in the PEA group were intraperitoneally injected with PEA (2 mg/kg). The recovery of motor function in SCI rats evaluated by Basso, Beattie and Bresnahan locomotor rating scale (BBB scale); Hematoxylin-eosin staining (scale bar = 50 μm); Nissl staining;. The body weight of the rats was recorded and the animal behavior, including 50% withdrawal threshold and withdrawal latency, was analyzed in the rats. ‘*’ indicates p < 0.05.