Research Paper Volume 13, Issue 22 pp 24640—24654

PPARα agonist relieves spinal cord injury in rats by activating Nrf2/HO-1 via the Raf-1/MEK/ERK pathway

PPARα agonist relieved inflammatory responses in SCI rats by inhibiting NF-κB expression. (A and B) The rats were randomly divided into sham-operation group (Sham group), rat SCI model group (SCI group), SCI + PPARα agonist PEA group (PEA group). The SCI rat model was established using modified Allen's method. The rats in the PEA group were intraperitoneally injected with PEA (2 mg/kg). The recovery of motor function in SCI rats evaluated by BBB scale; The levels of serum inflammatory factors (interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α)) detected by ELISA; The protein expression and phosphorylation levels of NF-κB detected by Western Blotting in spinal cord tissues; ‘*’ indicates p

Figure 2. PPARα agonist relieved inflammatory responses in SCI rats by inhibiting NF-κB expression. (A and B) The rats were randomly divided into sham-operation group (Sham group), rat SCI model group (SCI group), SCI + PPARα agonist PEA group (PEA group). The SCI rat model was established using modified Allen's method. The rats in the PEA group were intraperitoneally injected with PEA (2 mg/kg). The recovery of motor function in SCI rats evaluated by BBB scale; The levels of serum inflammatory factors (interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α)) detected by ELISA; The protein expression and phosphorylation levels of NF-κB detected by Western Blotting in spinal cord tissues; ‘*’ indicates p < 0.05.