Research Paper Volume 13, Issue 22 pp 24640—24654

PPARα agonist relieves spinal cord injury in rats by activating Nrf2/HO-1 via the Raf-1/MEK/ERK pathway

PPARα agonist inhibited oxidative stress injury in SCI rats. (A and B) The rats were randomly divided into sham-operation group (Sham group), rat SCI model group (SCI group), SCI + PPARα agonist PEA group (PEA group). The SCI rat model was established using modified Allen's method. The rats in the PEA group were intraperitoneally injected with PEA (2 mg/kg). Serum content of Oxidative stress factors (superoxide dismutase (SOD), malondialdehyde (MDA) and myeloperoxidase (MPO)) detected by ELISA; The expression of reactive oxygen species (ROS) (acrylamide (ACR) and manganese superoxide dismutase (MnSOD)) detected by IHC in spinal cord tissues; ‘*’ indicates p

Figure 3. PPARα agonist inhibited oxidative stress injury in SCI rats. (A and B) The rats were randomly divided into sham-operation group (Sham group), rat SCI model group (SCI group), SCI + PPARα agonist PEA group (PEA group). The SCI rat model was established using modified Allen's method. The rats in the PEA group were intraperitoneally injected with PEA (2 mg/kg). Serum content of Oxidative stress factors (superoxide dismutase (SOD), malondialdehyde (MDA) and myeloperoxidase (MPO)) detected by ELISA; The expression of reactive oxygen species (ROS) (acrylamide (ACR) and manganese superoxide dismutase (MnSOD)) detected by IHC in spinal cord tissues; ‘*’ indicates p < 0.05.