Identification and replication of novel genetic variants of ABO gene to reduce the incidence of diseases and promote longevity by modulating lipid homeostasis

Xiaolin Ni; Chen Bai; Chao Nie; Liping Qi; Yifang Liu; Huiping Yuan; Xiaoquan Zhu; Liang Sun; Qi Zhou; Yan Li; Hefu Zhen; Huabing Su; Rongqiao Li; Rushu Lan; Guofang Pang; Yuan Lv; Wei Zhang; Fan Yang; Yao Yao; Chen Chen; Zhaoping Wang; Danni Gao; Nan Zhang; Shenqi Zhang; Li Zhang; Zhu Wu; Caiyou Hu; Yi Zeng; Ze Yang

doi:doi:10.18632/aging.203700

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Research Paper Volume 13, Issue 22 pp 24655—24674

Identification and replication of novel genetic variants of ABO gene to reduce the incidence of diseases and promote longevity by modulating lipid homeostasis

Figure 1. Association analysis identified ABO as the longevity-associated gene. (A) Manhattan plot of Genome-Wide Association Studies (GWAS) on chromosome 9; (B) Linkage Disequilibrium (LD) analysis of the four variants. a: LD map of centenarians; b: LD map of nonagenarians; c: LD map of longevity; d: LD map of young controls. (C) Interaction analysis of the four variants in the three-dimensional genome. The red triangle box shows the Topologically Associating Domains (TAD) region on the ABO gene.