Research Paper Volume 13, Issue 22 pp 24655—24674

Identification and replication of novel genetic variants of ABO gene to reduce the incidence of diseases and promote longevity by modulating lipid homeostasis

The possible mechanism or interactive pathway from relevant information on ABO and plasma lipids phenotype. Mechanism of action for ABO variants may result in the vWF/ADAMTS13 and sE-selectin/ICAM1 functional change. Lastly, two pathways involving vWF/ADAMTS13 and the inflammatory markers (sE-selectin/ICAM1) that co-regulated lipid levels by O-linked glycosylation and effects on each other were speculated.

Figure 4. The possible mechanism or interactive pathway from relevant information on ABO and plasma lipids phenotype. Mechanism of action for ABO variants may result in the vWF/ADAMTS13 and sE-selectin/ICAM1 functional change. Lastly, two pathways involving vWF/ADAMTS13 and the inflammatory markers (sE-selectin/ICAM1) that co-regulated lipid levels by O-linked glycosylation and effects on each other were speculated.