Research Paper Volume 13, Issue 22 pp 24686—24709

Genomic mutation features identify distinct BRCA-associated mutation characteristics in endometrioid carcinoma and endometrioid ovarian carcinoma


Figure 3. Distinct BRCA-associated mutation characteristics and PARPi sensitivity in EC and EnOC. (A) The PPI network of eight BRCA-related genes. (B) GO enrichment analysis of the eight genes. (C) Point mutation frequency of these genes in EC and EnOC. (D) The mutant status of these eight genes and IC50 values in different cell lines derived from EC and EnOC. Orange square: with a mutation; gray square: without a mutation. (E) The IC50 values of various cell line to Olaparib, Talazoparib, Rucaparib and veliparib. Cell lines derived from EnOC were marked in blue and cell lines derived from EC were marked in red.