Research Paper Volume 13, Issue 22 pp 24753—24767

Fisetin inhibits the proliferation, migration and invasion of pancreatic cancer by targeting PI3K/AKT/mTOR signaling

Fisetin represses the PI3K/AKT/mTOR cascade in PANC-1 cells. (A, D) Western blot evaluation of key proteins in PANC-1 cells inoculated with 0, 50 and 100μM fisetin for 24 h. (B) Histogram illustrating p-JAK2/JAK2 ratio. (C) Histogram illustrating p-AKT/AKT ratio. (E) Histogram illustrating PI3K protein content. (F) Histogram exhibiting p-mTOR/mTOR ratio. All experiments were replicated thrice and data are given as means±SD. ns P>.05, **P

Figure 7. Fisetin represses the PI3K/AKT/mTOR cascade in PANC-1 cells. (A, D) Western blot evaluation of key proteins in PANC-1 cells inoculated with 0, 50 and 100μM fisetin for 24 h. (B) Histogram illustrating p-JAK2/JAK2 ratio. (C) Histogram illustrating p-AKT/AKT ratio. (E) Histogram illustrating PI3K protein content. (F) Histogram exhibiting p-mTOR/mTOR ratio. All experiments were replicated thrice and data are given as means±SD. ns P>.05, **P<.01, ***P<.001, ****P<.0001, in contrast with the controls.