Research Paper Volume 13, Issue 22 pp 24815—24828

Atorvastatin combined with dexamethasone promote hematoma absorption in an optimized rat model of chronic subdural hematoma

The dynamic change in hematoma volume in the chronic subdural hematoma model. (A) The MRI (GRE sequence) in the IM group. The part circled in red is the mixture of Matrigel and cells located in the subdural cavity of the rat; at this time, there is no blood signal in the subdural cavity. (B–E) Dynamic MRI (GRE) on the 3rd, 5th, 7th and 14th days after the establishment of the model. The part circled in red is the hematoma formed by spontaneous hemorrhage in the subdural region, in which the thickness and volume of the hematoma peaked at 5 d post-injury. At 14 d, most of the hematoma had been absorbed. (F) The dynamic change in the hematoma volume of the rats after modeling. IM: immediately after modeling. ** indicates p

Figure 2. The dynamic change in hematoma volume in the chronic subdural hematoma model. (A) The MRI (GRE sequence) in the IM group. The part circled in red is the mixture of Matrigel and cells located in the subdural cavity of the rat; at this time, there is no blood signal in the subdural cavity. (BE) Dynamic MRI (GRE) on the 3rd, 5th, 7th and 14th days after the establishment of the model. The part circled in red is the hematoma formed by spontaneous hemorrhage in the subdural region, in which the thickness and volume of the hematoma peaked at 5 d post-injury. At 14 d, most of the hematoma had been absorbed. (F) The dynamic change in the hematoma volume of the rats after modeling. IM: immediately after modeling. ** indicates p < 0.01 compared with the IM group, and *** indicates p < 0.001 compared with the IM group. IM indicates immediate MRI images after the establishment of the model.