Research Paper Volume 13, Issue 22 pp 24850—24865

Long noncoding RNA NEAT1 inhibits the acetylation of PTEN through the miR-524-5p /HDAC1 axis to promote the proliferation and invasion of laryngeal cancer cells


Figure 1. NEAT1 was upregulated in laryngocarcinoma. (A) The expression of lncRNA NEAT1 in laryngocarcinoma tissues and normal adjacent tissues was detected using qPCR. (n=20). (B) QPCR was used to detect the expression of NEAT1 in laryngocarcinoma patients with different stage tumors. (C) The level of NEAT1 was validated by in situ hybridization histochemistry in tissue biopsies. (D) The levels of NEAT1 in normal nasopharyngeal epithelial cell line (NP69) and laryngocarcinoma cell lines (TU212, SNU899, M2E and SNU46). ** P < 0.01 versus normal adjacent tissues, or laryngocarcinoma patients with stage I/II, or NP69.