Research Paper Volume 13, Issue 22 pp 24850—24865

Long noncoding RNA NEAT1 inhibits the acetylation of PTEN through the miR-524-5p /HDAC1 axis to promote the proliferation and invasion of laryngeal cancer cells


Figure 5. Overexpression of miR-524-5p reversed the promotive effects of NEAT1 overexpression on cell proliferation and invasion. (A) The level of miR-524-5p was analyzed after TU212 cells transfected with pcDNA-NEAT1 or/and miR-524-5p mimic. (B) Cell proliferation was detected with CCK-8 assay. (C) Transwell assay was used to evaluate cell invasion ability. (D) Apoptosis rates of TU212 cells. * P < 0.05, ** P < 0.01 versus Vector and NC-mimic or Vector and miR-524-5p mimic.