Research Paper Volume 13, Issue 22 pp 24866—24881

A scoring model based on ferroptosis genes for prognosis and immunotherapy response prediction and tumor microenvironment evaluation in liver hepatocellular carcinoma


Figure 6. Application of the ferroptosis scoring model in clinic and prospect of immunotherapy. (A, B) The Kaplan-Meier curve was adopted to analyze the survival of I-IV liver cancer patients in the high and low ferrscore groups (P < 0.001). (C, D) The Wilcoxon test was performed to analyze the expression of PD-1/PD-L1 in the high and low ferrscore groups, and the difference showed statistical significance (P < 0.05). (E, F) Patients with low ferrscore received the PD-1, and these patients having received the combination of the PD-1 and the CTLA4 achieved more effective results than patients with high ferrscore. In panel (G), no difference was reported in the CTLA4 treatment between high and low ferrscore groups (P = 0.058).