Research Paper Volume 13, Issue 22 pp 24866—24881

A scoring model based on ferroptosis genes for prognosis and immunotherapy response prediction and tumor microenvironment evaluation in liver hepatocellular carcinoma

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Figure 6. Application of the ferroptosis scoring model in clinic and prospect of immunotherapy. (A, B) The Kaplan-Meier curve was adopted to analyze the survival of I-IV liver cancer patients in the high and low ferrscore groups (P < 0.001). (C, D) The Wilcoxon test was performed to analyze the expression of PD-1/PD-L1 in the high and low ferrscore groups, and the difference showed statistical significance (P < 0.05). (E, F) Patients with low ferrscore received the PD-1, and these patients having received the combination of the PD-1 and the CTLA4 achieved more effective results than patients with high ferrscore. In panel (G), no difference was reported in the CTLA4 treatment between high and low ferrscore groups (P = 0.058).