Research Paper Volume 13, Issue 23 pp 25072—25088

Construction and validation of a metabolic gene-associated prognostic model for cervical carcinoma and the role on tumor microenvironment and immunity


Figure 6. The relationship between the MGPM-based risk score and tumor microenvironment and immune cell infiltration. (A) Kaplan-Meier survival curve was utilized to evaluate the prognosis of the tumor microenvironment, the result showed low-ESTIMATEScore had a shorter OS. (B) The distribution of ESTIMATEScore according to clinicopathological features (M). (C) The difference of ESTIMATEScore in low- and high-risk groups. (D) Kaplan-Meier survival analysis of ESTIMATEScore in combined with a risk score. (E) Violin plot showed the ratio differentiation of 21 types of immune cells between CC tumor samples in low- or high-risk groups, and Wilcoxon rank-sum was applied for the significance test. (F) Prognosis-related immune-infiltrating cells. (G) The correlation analysis between 21 types of immune-infiltrating cells and risk score, ESTIMATEScore and MGPM-based risk signature genes. (H) Immunotherapy score of low- and high-risk groups based on TCIA database.