Research Paper Volume 13, Issue 23 pp 25089—25105

The isoflavone puerarin exerts anti-tumor activity in pancreatic ductal adenocarcinoma by suppressing mTOR-mediated glucose metabolism


Figure 7. Puerarin controls glucose metabolism in PCCs. (AD) Glucose metabolism assay showing downregulated levels of OCR, basal respiration, spare respiration, maximal respiration, and ATP production in puerarin-treated PDACs. (EH) Glucose metabolism assay showing reduced ECAR, basal glycolysis, and compensatory glycolysis in puerarin-treated PDACs. (I) Protein expression of GLUT1 and HIF-1α in puerarin-treated PDACs. The data are presented as the mean ± standard deviation and analyzed by one-way ANOVA with Bonferroni’s post-hoc test and two-sided Student’s t-test. *P < 0.05, **P < 0.01, and ***P < 0.001.