Editorial Volume 13, Issue 22 pp 24477—24479

Figure 1. Dynamics of the Kras^G12D-expressing pancreatic cells in the organoid-based carcinogenesis model. Pancreatic organoids from Kras^LSL-G12D/+ mice (black) and Kras^LSL-G12D/+; Trp53^fl/fl mice (red) were lentivirally transduced with Cre. Positive selection for Kras^G12D-expressing cells was observed in a context-dependent manner. ERN(-), organoid culture with culture medium lacking EGF, Rsondin-1, and Noggin; PDA, pancreatic ductal adenocarcinoma; PanIN, pancreatic intraepithelial neoplasia.