Editorial Volume 13, Issue 22 pp 24477—24479

Twists and turns in Kras-driven tumor initiation


Figure 1. Dynamics of the KrasG12D-expressing pancreatic cells in the organoid-based carcinogenesis model. Pancreatic organoids from KrasLSL-G12D/+ mice (black) and KrasLSL-G12D/+; Trp53fl/fl mice (red) were lentivirally transduced with Cre. Positive selection for KrasG12D-expressing cells was observed in a context-dependent manner. ERN(-), organoid culture with culture medium lacking EGF, Rsondin-1, and Noggin; PDA, pancreatic ductal adenocarcinoma; PanIN, pancreatic intraepithelial neoplasia.