Research Paper Volume 13, Issue 23 pp 25153—25179

A circadian rhythm-related gene signature associated with tumor immunity, cisplatin efficacy, and prognosis in bladder cancer


Figure 4. Clinical association of CRRS. (A) The heatmap indicating CRRS was significantly associated with age, gender, tumor grade, tumor stages, pathological T stages, and M stages utilizing Chi-square tests. (BF). The time-dependent ROC analyses indicated the CRRS showed superiority over other clinical features in predicting the 1- (B), 2- (C), 3- (D), 4- (E), and 5-year (F) overall survival rate. ROC, receiver operating curve; CRRS, circadian rhythm-related score. *, P < 0.05; **, P < 0.01; ***, P < 0.001.