Figure 6. Cisplatin efficacy and CRRS. (A) The patients with high CRRS were more sensitive to cisplatin, doxorubicin, gemcitabine, and vinblastine, while the CRRS was positively associated with the sensitivity of methotrexate. (B) The evaluated CRRS and risk stratification of 20 BCa cell lines. (C) The cell lines with low CRRS exhibited high IC50 values via Wilcoxon signed-rank test. (D) The Spearman correlation analysis between CRRS and IC50 values among 20 BCa cell lines. (E) The patients with complete response had higher CRRS than those with stable disease. (F) The mRNA expression of the 16 CRRS genes after the treatment with 20μM cisplatin in T24 cells. CRRS, circadian rhythm-related score; IC50, half inhibitory concentration; BCa, bladder cancer.