Research Paper Volume 13, Issue 23 pp 25195—25212
YY1 and eIF4A3 are mediators of the cell proliferation, migration and invasion in cholangiocarcinoma promoted by circ-ZNF609 by targeting miR-432-5p to regulate LRRC1
Figure 1. Circ-ZNF609 was significantly high expression in CCA and associated with clinicopathological characteristics. (A) Schematic representation of circ-ZNF609 genomic structure. (B) The circ-ZNF609 and ZNF609 expression were detected through using the qRT-PCR in CCA cells treated with RNase R. (C) qRT-PCR was used to detect the relative expression of circ-ZNF609 in CCA tumor tissues and adjacent normal tissues. (D) Circ-ZNF609 expression of patients with different TNM stages. (E) Circ-ZNF609 expression of patients with or without lymph node metastasis. (F) The overall survival of high and low circ-ZNF609 expression group patients. (G) The correlation between circ-ZNF609 expression and survival time of CCA patients. (H) The ROC curve of circ-ZNF609 detection as a prognostic biomarker. (I) The ROC curve of CA19-9 detection as a prognostic biomarker. (J) The ROC curve of circ-ZNF609+CA19-9 detection as a prognostic biomarker. **P< 0.01; ***P< 0.001.