Priority Research Paper Volume 13, Issue 22 pp 24485—24499

Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test


Figure 6. 3D scatter plot of the covariates influencing CaAKG treatment efficacy. The x-axis refers to the difference, in years, between the chronological and biological ages at baseline (a patient in an older state will have larger positive value). The y-axis depicts the effect of CaAKG treatment in terms of years that the methylation age decreased (higher values indicate larger benefits). The z-axis is the chronological age at baseline (older patients will be “deeper”). The 3D plane was traced by using the linear regression of both covariates to treatment effect.