Research Paper Volume 13, Issue 23 pp 25241—25255

Endothelial cell–derived exosomal circHIPK3 promotes the proliferation of vascular smooth muscle cells induced by high glucose via the miR-106a-5p/Foxo1/Vcam1 pathway


Figure 1. HG promotes exosomes secretion in MAECs. (A) CCK-8 was used to detect cell viability in VSMCs co-cultured with MAECs (**p < 0.01 MAECs vs. NC). (B) Cell viability was detected by Edu assay. (C) NTA measured the size distribution of exosomes from an HG or NG condition. (D) Western blot analysis detected the expression of exosome markers CD63 and TSG 101.