Research Paper Volume 13, Issue 23 pp 25004—25024

An efficient, non-invasive approach for in-vivo sampling of hair follicles: design and applications in monitoring DNA damage and aging


Figure 4. Gene expression changes (mRNA level) in murine hair follicles after in vivo ionizing irradiation. Data are expressed in boxplot graphs showing median, first quartile data distribution and maximum and minimum values of fold changes relative to expression at time zero (immediately before irradiation) normalized using HPRT mRNA levels. Results of paired t-tests of the significance of differences between indicated groups and times (relative to the zero-time point) are also depicted (*p<0.05, **p<0.01, ***p<0.001).