Research Paper Volume 13, Issue 23 pp 25291—25303

Sorbitol accumulation decreases oocyte quality in aged mice by altering the intracellular redox balance


Figure 3. Fertilization and subsequent blastocyst formation of IVM oocytes of aged mice. (A) Early embryo development of IVM oocytes after fertilization. (B) The rates of 2-cell embryos (the number of 2-cell embryos/the total number of oocytes) in young IVM oocytes (young), aged IVM oocytes (aged), and aged IVM oocytes treated with sorbinil (sorbinil). (C) The rates of blastocyst formation (the number of blastocysts/the number of 2-cell embryos) in the above three groups. All experiments were repeated at least three times. Scale bar = 50 μm, **P < 0.01.