Research Paper Volume 13, Issue 23 pp 25325—25341

Artesunate treatment ameliorates ultraviolet irradiation-driven skin photoaging via increasing β-catenin expression


Figure 5. Art treatment inhibits cell apoptosis and enhances proliferation of UVB-irradiated HaCaT cells through increasing β-catenin expression. (A, B) Flow cytometry of apoptotic HaCaT cells in control group, UV group, UV + sh-NC group, UV + sh-β-catenin group, UV + sh-NC + Art group, UV + sh-β-catenin + Art group, UV + XAV-939 group and UV + XAV-939 + Art group. (C) CCK-8 assay for HaCaT cell viability in each group. (D, E) Hoechst/PI staining for morphological changes of HaCaT cell apoptosis in each group. Scale bar: 100 μm. Magnification: 200×. Ns: not significant; ****p<0.0001.