Research Paper Volume 13, Issue 23 pp 25342—25364

Figure 1. Galangin inhibits UVB/H₂O₂-induced cytotoxicity in HS68 human dermal fibroblasts. (A) The chemical structure of galangin. (B) Cell viability of HS68 cells treated with different concentrations of galangin (10, 20, 30, 40, 50 μM) for 24 h. (C and D) Cell viability of HS68 cells exposed to different doses of H₂O₂ (100, 150, 200, 250, 300 μM) or irradiated with UVB (25, 30, 40, 50, 60 J/cm²) for 24 h. (E and F) Cell viability of HS68 cells exposed to H₂O₂ (200 μM) or irradiated with UVB (40 J/cm²) for 1 h and then treated with galangin (10, 20, 30 μM) for 23 h. The cytoprotective effects of galangin were determined by the MTT assay. Control cells were assigned 100% viability. Values are shown as mean ± SE. Quantification of the results is shown (n = 3) ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 vs. untreated control cells; ^##P < 0.01, ^###P < 0.001 vs. H₂O₂ or UVB-treated cells.