Research Paper Volume 13, Issue 23 pp 25342—25364

Protective effects of galangin against H2O2/UVB-induced dermal fibroblast collagen degradation via hsa-microRNA-4535-mediated TGFβ/Smad signaling


Figure 11. Topical galangin application attenuates UVB-induced skin hyperplasia and collagen degradation in the dorsal skin of C57BL6/J nude mice. Skin tissues were serially sectioned and stained with H&E, Masson’s trichrome, and immunohistochemically for p-Smad2/3 Smad4 and β-gal. H&E staining showed epidermal thickness. Double-headed red arrows indicate the epidermal thickening. Masson’s trichrome staining showed the collagen fiber content in dermal layers. Collagen fibers appear blue. LD, low dose; HD, high dose.