Research Paper Volume 13, Issue 23 pp 25342—25364

Protective effects of galangin against H2O2/UVB-induced dermal fibroblast collagen degradation via hsa-microRNA-4535-mediated TGFβ/Smad signaling


Figure 13. Schematic diagram for the mechanism of galangin action. Galangin enhances TGFβ/Smad collagen synthesis pathways by reducing H2O2-induced hsa-microRNA-4535 to improve photoaging in human skin dermal fibroblast. Abbreviations: ECM: extracellular matrix; TGFβ: transforming grown factor beta; TβRI: TGFβ receptor type I; TβRII: TGFβ receptor type II.