Research Paper Volume 13, Issue 23 pp 25408—25425

lncRNA CASC7 regulates pathological progression of ox-LDL-stimulated atherosclerotic cell models via sponging miR-21 and regulating PI3K/Akt and TLR4/NF-κB signaling pathways


Figure 1. Differential expression profile of lncRNAs between AS and healthy patients. (A) The differential genes are represented by volcano plots. Gray points are genes with P values ≥ 0.05. Green point are genes with absolute fold changes ≥ 2 and P values < 0.05. The red dots are genes with fold changes ≥ 2 and P values < 0.05. (B) A heatmap showing differentially expressed lncRNAs. Green and red colors stand for down-regulation and up-regulation, respectively. (C) qRT-PCR was performed to detect the expression of lncRNAs in AS serum. (D) An ROC analysis of lncRNAs expression to differentiate between AS and healthy controls. Results are expressed as mean ± SD. *P < 0.05.