Research Paper Volume 13, Issue 23 pp 25496—25517

A novel 6-gene signature derived from tumor-infiltrating T cells and neutrophils predicts survival of bladder urothelial carcinoma


Figure 2. (A) Coefficients of the 6 covariates included in the Cox’s proportional hazards regression model. The table listed all the 10 genes with prognostic prediction value for bladder cancer according to univariate Cox regression analysis (P < 0.01) in the TCGA-BLCA dataset. Lasso regression analysis further selected the combination of 8 genes which were annotated in bold. Among the 8 genes, a model integrated 6 genes were ultimately constructed using multivariate Cox regression analysis. (B) The forest plot showing the prognostic value of the 6 genes. Multivariate Cox regression analysis considering gene expression levels as well as several clinicopathologic features was conducted to see if a gene was an independent prognostic factor for BUC.