Research Paper Volume 13, Issue 24 pp 25763—25777

Retinal drusen in patients with chronic myeloproliferative blood cancers are associated with an increased proportion of senescent T cells and signs of an aging immune system


Figure 2. Barplots of (A) CD4 T cell differentiation profile. (B) CD8 T cell differentiation profile. (C) Loss of costimulatory markers in CD4 and CD8 T cells. (D) CD56 expression in CD4 and CD8 cells Statistically significant p-values are shown above bar plots. Statistical comparisons between groups: Kruskal Wallis test or robust linear regression if the outcome were age-dependent and Wilcoxon rank-sum test for multiple comparisons. Abbreviations: nAMD: neovascular AMD; iAMD: intermediate AMD; MPN: myeloproliferative neoplasms; MPNd: Patients with MPN and drusen; MPNn: patients with MPN and normal retinas; Naïve: naïve T cells; CM: central memory T cells; EM: effector memory T cells; EMRA: effector memory CD45Ra+ T cells.