Figure 2. Landscape of N6-methyladenosine (m6A) regulators in patients with sarcoma. (A) Regulation of m6A regulators and their biological functions in RNA metabolism. A total of 23 known m6A regulators, including 13 readers, 8 writers, and 2 erasers. m6A methylation involves multiple stages of the RNA life cycle, including pre-mRNA shearing, pre-mRNA splicing, pre-mRNA transport, RNA translation, RNA degradation, etc. (B) Copy number variation (CNV) mutations in 23 m6A regulators. (C) The location of CNV alterations of m6A regulators on chromosomes. (D) Differential expression levels of 23 m6A regulators between normal tissues (Adipose and muscle tissues) and tumor tissues (sarcoma samples). Asterisks represent the statistical P-values (*P < 0.05; **P < 0.01; ***P < 0.001).