Research Paper Volume 14, Issue 1 pp 368—388

LINC02362 attenuates hepatocellular carcinoma progression through the miR-516b-5p/SOSC2 axis


Figure 12. Schematic working model of LINC02362/miR-516b-5p/SOCS2 axis on HCC progression. Schematic model showing the mechanism how the LINC02362/miR-516b-5p/SOCS2 axis regulate the HCC progression. Upon the upregulation of LINC02362, downstream target miRNA miR-516b-5p is sponged and the levels are decreased in the HCC cells. As miR-516b-5p is a negative regulator of SOCS2, the SOCS2 mRNA and protein levels are enhanced by LINC02362, resulting in the mitigation of cell proliferation and metastasis and augment of cell apoptosis of HCC cells.