Research Paper Volume 14, Issue 6 pp 2793—2804

Local anesthetic levobupivacaine inhibits stemness of osteosarcoma cells by epigenetically repressing MAFB though reducing KAT5 expression


Figure 2. Levobupivacaine induces osteosarcoma cell apoptosis and represses invasion. (AD) MG63 and U2OS cells were treated with levobupivacaine (2 mM). (A, B) Cell apoptosis was analyzed by Annexin V/PI apoptosis detection kit. (C, D) Cell invasion and migration were detected by transwell assays. mean ± SD, ** P < 0.01.