Research Paper Volume 14, Issue 8 pp 3569—3596
Effective biomarkers and therapeutic targets of nerve-immunity interaction in the treatment of depression: an integrated investigation of the miRNA-mRNA regulatory networks
Figure 4. Volcano map and heat map of DE-mRNAs. (A) The volcano plot using log2|FC|≥2 and an adjusted p < 0.05 as cut off values for miRNAs; red dots represent upregulated DE-mRNAs (n = 181), blue dots represent downregulated DE-mRNAs (n = 205), and black dots represent non-DEmiRs. (B) A heat map depicting the expression variety of 386 DE-mRNAs across four miRNA chips; the color scale from blue to red represents expression levels ranging from low to high.