Editorial Volume 14, Issue 9 pp 3724—3725

Figure 1. The new role of YAP in astrocytic senescence and AD. YAP is a protein that participates in various physiological and pathological processes, and functions in cell proliferation, differentiation, apoptosis, inflammation, neuroregeneration, tumorigenesis and progression, and stress. Moreover, YAP plays an important role in cellular senescence as well. Down-regulation of YAP promotes senescence of astrocytes, and may increase deposition of Aβ, which in turn, aggravates senescence of astrocytes, and such complex interaction contribute to AD pathogenesis.