Research Paper Volume 14, Issue 11 pp 4714—4727

TLR3 deletion inhibits programmed necrosis of brain cells in neonatal mice with sevoflurane-induced cognitive dysfunction


Figure 7. TLR3 deletion inhibited RIP3 phosphorylation and reduced programmed necrosis of hippocampal neurons by regulating TRIF and SHP2 expressions. (A) Expressions of TLR3, p-TRIF, SHP2, p-RIP3 and CaMKII in the hippocampal neurons. (B) Expressions of NLRP3, GSDMD, Caspase-1, Caspase-4 and Caspase-11 in the hippocampal neurons. **p < 0.01.