Research Paper Volume 14, Issue 11 pp 4653—4672

Histone deacetylase 4 reverses cellular senescence via DDIT4 in dermal fibroblasts


Figure 2. Integrative transcriptome analysis identifies DDIT4 as a candidate target. (A) Venn diagram showing the relationships among DEGs identified from the three comparisons: HDAC4 overexpression versus knockdown (HDAC4 targets); UV-induced senescent versus control HDFs (UV-induced senescence); and H2O2-induced senescent versus control HDFs (H2O2-induced senescence). Numbers in parentheses, numbers of DEGs. (B) Differential expression patterns of the five overlapping DEGs in the three comparisons (see legend). (C) The mRNA levels of DDIT4, GINS2, and PGAP6 analyzed by RT-PCR (n=5). Data represent the mean ± SE (n = 5, * P < 0.05, ** P <0.01, *** P <0.001). NC: scrambled control.