Research Paper Volume 14, Issue 13 pp 5523—5536

Long non-coding RNA ZNF674-AS1 antagonizes oxaliplatin resistance of gastric cancer via regulating EZH2-mediated methylation of CHST7

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Figure 1. Reduced ZNF674-AS1 correlated to oxaliplatin resistance and poor outcome in gastric cancer. (A) RNA level of ZNF674-AS1 in 31 oxaliplatin-resistant GC tissues and 39 oxaliplatin-sensitive GC tissues was examined by qRT-PCR. (B) Overall survival of GC patients with lower or higher level of ZNF674-AS1was determined by Kaplan-Meier’s analysis. (C) ZNF674-AS1 expression in six GC cell lines (oxaliplatin-resistant cells or parental AGS, MKN-45, and MKN-28) and normal human gastric epithelial cell lines (GES) was determined by qRT-PCR. Student’s t-test for (A, C).