Research Paper Volume 14, Issue 14 pp 5710—5726

Sofosbuvir induces gene expression for promoting cell proliferation and migration of hepatocellular carcinoma cells

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Figure 2. Cell migration assay in sofosbuvir treated hepatoma cells using Interferon-α and ribavirin as controls. Cell migration assay was performed in OR-6 cells (A) and Huh 7.5.1 cells (B) treated with different doses of SOF (0.1 to 2.5 μM), interferon-α (1 to 1000 IU) and ribavirin (0.1 to 100 μM) for 24 hrs in the left panel. The quantitative results for migratory distance of (C) OR-6 cells or (D) Huh 7.5.1 were calculated with ImageJ software and expressed as the mean ± SEM from three independent experiments. (*p < 0.05; **p < 0.01; ***p < 0.001).