Research Paper Volume 14, Issue 14 pp 5710—5726

Sofosbuvir induces gene expression for promoting cell proliferation and migration of hepatocellular carcinoma cells


Figure 2. Cell migration assay in sofosbuvir treated hepatoma cells using Interferon-α and ribavirin as controls. Cell migration assay was performed in OR-6 cells (A) and Huh 7.5.1 cells (B) treated with different doses of SOF (0.1 to 2.5 μM), interferon-α (1 to 1000 IU) and ribavirin (0.1 to 100 μM) for 24 hrs in the left panel. The quantitative results for migratory distance of (C) OR-6 cells or (D) Huh 7.5.1 were calculated with ImageJ software and expressed as the mean ± SEM from three independent experiments. (*p < 0.05; **p < 0.01; ***p < 0.001).