Research Paper Volume 14, Issue 14 pp 5727—5748

The therapeutic effect of Fufang Zhenshu Tiaozhi (FTZ) on osteoclastogenesis and ovariectomized-induced bone loss: evidence from network pharmacology, molecular docking and experimental validation


Figure 8. FTZ treatment improves ovariectomized (OVX)-induced bone loss in vivo. (AC) Serum levels of TRAP, TNF-α, IL6 in different groups were detected by ELISA. (DF) Representative μCT images showing the bone mass of Sham, OVX, FTZ groups, and indicating that the bone loss was prevented by FTZ treatment. (GJ) μCT quantitative parameters for bone microstructure including BV/TV, BS/BV, Tb.N, and Tb.Sp (n = 4 per group). *p < 0.05, **p < 0.01, ***p < 0.001. Abbreviations: BV/TV: bone volume per tissue volume; BS/BV: bone surface per bone volume; Tb.N: trabecular number; Tb.Sp: trabecular spacing.