Research Paper Volume 14, Issue 14 pp 5783—5799

The miR-590-3p/CFHR3/STAT3 signaling pathway promotes cell proliferation and metastasis in hepatocellular carcinoma


Figure 1. Downregulation of CFHR3 is associated with a poor prognosis of HCC patients. (A) Differentially expressed genes (DEGs) between HCC and normal liver tissues in TCGA-LIHC cohort are shown as a volcano plot. (B) The overlap between DEGs, the most significant overall survival (OS) related genes, and the most significantly disease-free survival (DFS) related genes in the TCGA database is displayed as a Venn diagram. (C) The difference in CFHR3 transcript levels between normal liver and HCC tissues is presented as a box plot. (DF) The difference in CFHR3 transcript levels between HCC subgroups, including tumor size (D, T1-2, and T3-4), tumor recurrence (E, non-recurrence and recurrence), and clinical stage (F, stage I-II, and stage III-IV) is presented as a box plot, respectively. (G, H) The difference in OS rates (G) or DFS rates (H) between HCC patients with low and high CFHR3 transcript levels in HCC tissues is shown as a survival curve, respectively. (I, J) The independent prognostic factor for OS (I) and DFS (J) of HCC patients, based on the multivariate Cox proportional hazard model, is shown in each forest plot, respectively.