Research Paper Volume 14, Issue 14 pp 5855—5877

Protective effect of Astragalus membranaceus and Astragaloside IV in sepsis-induced acute kidney injury


Figure 1. Astragalus membranaceus protects against renal injury in CLP-induced sepsis. (A) Representative images of H&E staining of kidney sections obtained at 24 hours after CLP surgery following treatment with (250 mg/kg) Astragalus membranaceus. (B) Representative images of periodic acid Schiff’s staining reagent depicting basement membrane and brush border in kidney sections. (C) Semiquantitative analysis of tubular injury. (D) Representative images showing KIM-1 immunohistochemical staining results in kidney tissues. Serum creatinine (E) and Blood urea nitrogen (F) in mice were measured. (G) Serum IL-6 and IL-1β concentrations were measured by ELISA. Data are presented as the mean ± SEM (n = 6 per group, ***P < 0.001 compared to Sham group, ##P < 0.01, ###P < 0.001 compared to CLP group).