Research Paper Volume 14, Issue 14 pp 5908—5924

microRNA-497 prevents pancreatic cancer stem cell gemcitabine resistance, migration, and invasion by directly targeting nuclear factor kappa B 1


Figure 10. CSCs promotes tumor growth in vivo than in non-CSCs. A mouse model of Pancreatic cancer was established by subcutaneously inoculating CSCs and non-CSCs. (A) xenograft tumors of each group were shown; (B) Tumor volume was measured every week. (C) The mRNA level of miR-497/ NFkB1 /Ki67/ CD147/MMP-2 in tumors. **p < 0.01, compared to non-CSCs.