Research Paper Volume 14, Issue 14 pp 5908—5924

microRNA-497 prevents pancreatic cancer stem cell gemcitabine resistance, migration, and invasion by directly targeting nuclear factor kappa B 1


Figure 4. The miR-497 inhibitor significantly inhibited gemcitabine-induced decreases in CSC and non-CSC migration and invasion. CSCs and non-CSCs isolated from populations of AsPC-1 and BxPC-3 cells were transfected with NC or miR-497 inhibitor and then exposed to gemcitabine for 24 h. The migration (A) and invasion (B) capabilities of the cells were examined. ***P< 0.001, compared to the NC group; ###P< 0.001, compared to the NC+gemcitabine group. Data are shown as mean ± SEM. All experiments were repeated at least three independent experiments.