Research Paper Volume 14, Issue 14 pp 5925—5945

miR-21 upregulation exacerbates pressure overload-induced cardiac hypertrophy in aged hearts


Figure 5. The treatment of miR-21 antagomir mitigated angiotensin II (Ang II)-induced cardiac hypertrophy, especially in the aged mice. (A) The study design investigating the effects of miR-21 antagomir in young (12 week-old) and aged mice(50 week-old) of Ang II-induced pressure overload. The sequential changes of (B) systolic, (C) diastolic blood pressures, echocardiography derived (D) intraventricular septal thickness at diastole (IVSd), and (E) fractional shortening (FS) in young and old mice treated with miR-21 antagomir or not under Ang II-induced pressure overload. (F) The comparison of harvested hearts in mice of control, Ang II, miR-21 antagomir and Ang II+ miR-21 antagomir. *P < 0.05 for difference from each group (N = 4–6).