Research Paper Volume 14, Issue 14 pp 5641—5668

Figure 7. Gene set enrichment analysis for highly contributing CpGs. Each PC’s ranked CpG weights were translated to genes according to annotations, and pathway enrichment analysis was run for each PC. Here, the sparse consensus network of enriched curated GO and REAC terms across the 15 PCs is visualized. Annotated clusters of significant pathway similarities and high weights are labeled (5), along with the genes enriched within that group beyond the rest of the network. Each node is colored according to the enrichment score of that term, from PC1 (yellow) to PC15 (dark purple) according to the viridis color palette, with more color slices demonstrating enrichment across more PCs.