Research Paper Volume 14, Issue 15 pp 6028—6046
Ascorbic acid induces salivary gland function through TET2/acetylcholine receptor signaling in aging SAMP1/Klotho (-/-) mice
Figure 1. A comparison of the metabolites of ascorbic acid biosynthesis in aging mouse salivary glands. Metabolic profiling was conducted by CE-TOFMS using aging-accelerated mice (SAMP1/kl+/+, SAMP1/kl-/- 1 month, and SAMP1/kl-/- 2 months) (A–D) Changes in intermediates in ascorbic acid metabolism. The relative quantities of detected metabolites are represented as bar graphs (glucose 6-phosphate, UDP-glucuronic acid, D-glucuronic acid, and L-ascorbic acid). (E) Comparisons of the relative amount of ascorbic acid metabolites between SAMP1/kl+/+, SAMP1/kl-/- 1-month-old, and SAMP1/kl-/- 2-month-old mouse salivary glands.