Research Paper Volume 14, Issue 22 pp 8886—8899

Phosphoglycerate kinase 1 protects against ischemic damage in the gerbil hippocampus


Figure 4. In vivo mechanisms of Con-PGK1 and PEP-1-PGK1 on ischemia-induced damage in gerbils. Succinate dehydrogenase activity, pH, ATP, lactate, and malondialdehyde levels were assessed in the hippocampus of gerbils at various times after ischemia. The nuclear fraction of nuclear factor erythroid-2-related factor 2 was measured in the hippocampus using western blotting 1 d after ischemia. Data are analyzed by a one-way analysis of variance, followed by a Bonferroni’s post-hoc test (n = 6 per group; ap < 0.05, significantly different from the control group; bp < 0.05, significantly different from the vehicle-treated group; cp < 0.05, significantly different from the Con-PGK1-treated group). The bar graph represents the mean ± standard deviation.